Selectivity data for probe RO4938581 and control RO4991571
Coming soon
RO4938581
RO4938581 was screened at 10 µM.
Conclusion: Clean panel.
| Target protein | HGNC name | Species | % Inhibition at 10 µM |
|---|---|---|---|
| AAK1 | AAK1 | Homo sapiens | 4.0 |
| ABL1(E255K)-phosphorylated | ABL1 | Homo sapiens | 28.0 |
| ABL1(F317I)-nonphosphorylated | ABL1 | Homo sapiens | 1.0 |
| ABL1(F317I)-phosphorylated | ABL1 | Homo sapiens | 11.0 |
| ABL1(F317L)-nonphosphorylated | ABL1 | Homo sapiens | 6.0 |
| ABL1(F317L)-phosphorylated | ABL1 | Homo sapiens | 12.0 |
| ABL1(H396P)-nonphosphorylated | ABL1 | Homo sapiens | 32.0 |
| ABL1(H396P)-phosphorylated | ABL1 | Homo sapiens | 19.0 |
| ABL1(M351T)-phosphorylated | ABL1 | Homo sapiens | 0.0 |
| ABL1(Q252H)-nonphosphorylated | ABL1 | Homo sapiens | 10.0 |
| ABL1(Q252H)-phosphorylated | ABL1 | Homo sapiens | 12.0 |
| ABL1(T315I)-nonphosphorylated | ABL1 | Homo sapiens | 2.0 |
| ABL1(T315I)-phosphorylated | ABL1 | Homo sapiens | 16.0 |
| ABL1(Y253F)-phosphorylated | ABL1 | Homo sapiens | 0.0 |
| ABL1-nonphosphorylated | ABL1 | Homo sapiens | 28.0 |
| ABL1-phosphorylated | ABL1 | Homo sapiens | 40.0 |
| ABL2 | ABL2 | Homo sapiens | 0.0 |
| ACVR1 | ACVR1 | Homo sapiens | 7.0 |
| ACVR1B | ACVR1B | Homo sapiens | 1.0 |
| ACVR2A | ACVR2A | Homo sapiens | 2.0 |
| ACVR2B | ACVR2B | Homo sapiens | 23.0 |
| ACVRL1 | ACVRL1 | Homo sapiens | 0.0 |
| ADCK3 | COQ8A | Homo sapiens | 5.0 |
| ADCK4 | COQ8B | Homo sapiens | 2.0 |
| AKT1 | AKT1 | Homo sapiens | 3.0 |
| AKT2 | AKT2 | Homo sapiens | 0.0 |
| AKT3 | AKT3 | Homo sapiens | 10.0 |
| ALK | ALK | Homo sapiens | 25.0 |
| ALK(C1156Y) | ALK | Homo sapiens | 5.0 |
| ALK(L1196M) | ALK | Homo sapiens | 8.0 |
| ANKK1 | ANKK1 | Homo sapiens | 0.0 |
| AURKA | AURKA | Homo sapiens | 0.0 |
| AURKB | AURKB | Homo sapiens | 2.0 |
| AURKC | AURKC | Homo sapiens | 17.0 |
| AXL | AXL | Homo sapiens | 7.0 |
| BLK | BLK | Homo sapiens | 7.0 |
| BMP2K | BMP2K | Homo sapiens | 7.0 |
| BMPR1A | BMPR1A | Homo sapiens | 6.0 |
| BMPR1B | BMPR1B | Homo sapiens | 18.0 |
| BMPR2 | BMPR2 | Homo sapiens | 6.0 |
| BMX | BMX | Homo sapiens | 0.0 |
| BRAF | BRAF | Homo sapiens | 7.0 |
| BRAF(V600E) | BRAF | Homo sapiens | 26.0 |
| BRSK1 | BRSK1 | Homo sapiens | 7.0 |
| BRSK2 | BRSK2 | Homo sapiens | 0.0 |
| BTK | BTK | Homo sapiens | 8.0 |
| BUB1 | BUB1 | Homo sapiens | 0.0 |
| CAMK1 | CAMK1 | Homo sapiens | 5.0 |
| CAMK1D | CAMK1D | Homo sapiens | 3.0 |
| CAMK1G | CAMK1G | Homo sapiens | 4.0 |
| CAMK2A | CAMK2A | Homo sapiens | 10.0 |
| CAMK2B | CAMK2B | Homo sapiens | 17.0 |
| CAMK2D | CAMK2D | Homo sapiens | 4.0 |
| CAMK2G | CAMK2G | Homo sapiens | 17.0 |
| CAMK4 | CAMK4 | Homo sapiens | 3.0 |
| CAMKK1 | CAMKK1 | Homo sapiens | 4.0 |
| CAMKK2 | CAMKK2 | Homo sapiens | 7.0 |
| CASK | CASK | Homo sapiens | 0.0 |
| CDC2L1 | CDK11B | Homo sapiens | 12.0 |
| CDC2L2 | CDK11A | Homo sapiens | 0.0 |
| CDC2L5 | CDK13 | Homo sapiens | 5.0 |
| CDC42BPA | CDC42BPA | Homo sapiens | 7.0 |
| CDC42BPB | CDC42BPB | Homo sapiens | 11.0 |
| CDC42BPG | CDC42BPG | Homo sapiens | 0.0 |
| CDK11 | CDK19 | Homo sapiens | 0.0 |
| CDK2 | CDK2 | Homo sapiens | 10.0 |
| CDK3 | CDK3 | Homo sapiens | 11.0 |
| CDK4 | CDK4 | Homo sapiens | 0.0 |
| CDK4-cyclinD1 | CDK4 | Homo sapiens | 0.0 |
| CDK4/CCND3 | CDK4 | Homo sapiens | 0.0 |
| CDK5 | CDK5 | Homo sapiens | 0.0 |
| CDK7 | CDK7 | Homo sapiens | 0.0 |
| CDK8 | CDK8 | Homo sapiens | 16.0 |
| CDK9 | CDK9 | Homo sapiens | 22.0 |
| CDKL1 | CDKL1 | Homo sapiens | 22.0 |
| CDKL2 | CDKL2 | Homo sapiens | 18.0 |
| CDKL3 | CDKL3 | Homo sapiens | 0.0 |
| CDKL5 | CDKL5 | Homo sapiens | 0.0 |
| CHEK1 | CHEK1 | Homo sapiens | 0.0 |
| CHEK2 | CHEK2 | Homo sapiens | 8.0 |
| CHUK | CHUK | Homo sapiens | 5.0 |
| CIT | CIT | Homo sapiens | 12.0 |
| CLK1 | CLK1 | Homo sapiens | 1.0 |
| CLK2 | CLK2 | Homo sapiens | 5.0 |
| CLK3 | CLK3 | Homo sapiens | 2.0 |
| CLK4 | CLK4 | Homo sapiens | 41.0 |
| CSF1R | CSF1R | Homo sapiens | 0.0 |
| CSF1R-autoinhibited | CSF1R | Homo sapiens | 3.0 |
| CSK | CSK | Homo sapiens | 0.0 |
| CSNK1A1 | CSNK1A1 | Homo sapiens | 9.0 |
| CSNK1A1L | CSNK1A1L | Homo sapiens | 11.0 |
| CSNK1D | CSNK1D | Homo sapiens | 2.0 |
| CSNK1E | CSNK1E | Homo sapiens | 2.0 |
| CSNK1G1 | CSNK1G1 | Homo sapiens | 10.0 |
| CSNK1G2 | CSNK1G2 | Homo sapiens | 17.0 |
| CSNK1G3 | CSNK1G3 | Homo sapiens | 3.0 |
| CSNK2A1 | CSNK2A1 | Homo sapiens | 0.0 |
| CSNK2A2 | CSNK2A2 | Homo sapiens | 0.0 |
| DAPK1 | DAPK1 | Homo sapiens | 15.0 |
| DAPK2 | DAPK2 | Homo sapiens | 5.0 |
| DAPK3 | DAPK3 | Homo sapiens | 18.0 |
| DCLK1 | DCLK1 | Homo sapiens | 0.0 |
| DCLK2 | DCLK2 | Homo sapiens | 0.0 |
| DCLK3 | DCLK3 | Homo sapiens | 10.0 |
| DDR1 | DDR1 | Homo sapiens | 0.0 |
| DDR2 | DDR2 | Homo sapiens | 0.0 |
| DMPK | DMPK | Homo sapiens | 10.0 |
| DYRK1A | DYRK1A | Homo sapiens | 10.0 |
| DYRK1B | DYRK1B | Homo sapiens | 14.0 |
| DYRK2 | DYRK2 | Homo sapiens | 10.0 |
| EGFR | EGFR | Homo sapiens | 11.0 |
| EGFR(E746-A750del) | EGFR | Homo sapiens | 4.0 |
| EGFR(G719C) | EGFR | Homo sapiens | 0.0 |
| EGFR(G719S) | EGFR | Homo sapiens | 0.0 |
| EGFR(L747-E749del, A750P) | EGFR | Homo sapiens | 29.0 |
| EGFR(L747-S752del, P753S) | EGFR | Homo sapiens | 6.0 |
| EGFR(L747-T751del,Sins) | EGFR | Homo sapiens | 0.0 |
| EGFR(L858R) | EGFR | Homo sapiens | 16.0 |
| EGFR(L858R,T790M) | EGFR | Homo sapiens | 20.0 |
| EGFR(L861Q) | EGFR | Homo sapiens | 3.0 |
| EGFR(S752-I759del) | EGFR | Homo sapiens | 0.0 |
| EGFR(T790M) | EGFR | Homo sapiens | 9.0 |
| EIF2AK1 | EIF2AK1 | Homo sapiens | 0.0 |
| EIF2AK4(Kin.Dom.2,S808G) | EIF2AK4 | Homo sapiens | 7.0 |
| EPHA1 | EPHA1 | Homo sapiens | 0.0 |
| EPHA2 | EPHA2 | Homo sapiens | 13.0 |
| EPHA3 | EPHA3 | Homo sapiens | 0.0 |
| EPHA4 | EPHA4 | Homo sapiens | 3.0 |
| EPHA5 | EPHA5 | Homo sapiens | 0.0 |
| EPHA6 | EPHA6 | Homo sapiens | 0.0 |
| EPHA7 | EPHA7 | Homo sapiens | 3.0 |
| EPHA8 | EPHA8 | Homo sapiens | 0.0 |
| EPHB1 | EPHB1 | Homo sapiens | 0.0 |
| EPHB2 | EPHB2 | Homo sapiens | 2.0 |
| EPHB3 | EPHB3 | Homo sapiens | 0.0 |
| EPHB4 | EPHB4 | Homo sapiens | 1.0 |
| EPHB6 | EPHB6 | Homo sapiens | 0.0 |
| ERBB2 | ERBB2 | Homo sapiens | 0.0 |
| ERBB3 | ERBB3 | Homo sapiens | 2.0 |
| ERBB4 | ERBB4 | Homo sapiens | 0.0 |
| ERN1 | ERN1 | Homo sapiens | 4.0 |
| FER | FER | Homo sapiens | 2.0 |
| FES | FES | Homo sapiens | 0.0 |
| FGFR1 | FGFR1 | Homo sapiens | 0.0 |
| FGFR2 | FGFR2 | Homo sapiens | 8.0 |
| FGFR3 | FGFR3 | Homo sapiens | 0.0 |
| FGFR3(G697C) | FGFR3 | Homo sapiens | 0.0 |
| FGFR4 | FGFR4 | Homo sapiens | 0.0 |
| FGR | FGR | Homo sapiens | 0.0 |
| FLT1 | FLT1 | Homo sapiens | 7.0 |
| FLT3 | FLT3 | Homo sapiens | 7.0 |
| FLT3(D835H) | FLT3 | Homo sapiens | 26.0 |
| FLT3(D835V) | FLT3 | Homo sapiens | 9.0 |
| FLT3(D835Y) | FLT3 | Homo sapiens | 32.0 |
| FLT3(ITD) | FLT3 | Homo sapiens | 7.0 |
| FLT3(ITD,D835V) | FLT3 | Homo sapiens | 21.0 |
| FLT3(ITD,F691L) | FLT3 | Homo sapiens | 7.0 |
| FLT3(K663Q) | FLT3 | Homo sapiens | 12.0 |
| FLT3(N841I) | FLT3 | Homo sapiens | 9.0 |
| FLT3(R834Q) | FLT3 | Homo sapiens | 0.0 |
| FLT3-autoinhibited | FLT3 | Homo sapiens | 12.0 |
| FLT4 | FLT4 | Homo sapiens | 12.0 |
| FRK | FRK | Homo sapiens | 0.0 |
| FYN | FYN | Homo sapiens | 0.0 |
| GAK | GAK | Homo sapiens | 10.0 |
| GRK1 | GRK1 | Homo sapiens | 2.0 |
| GRK2 | GRK2 | Homo sapiens | 13.0 |
| GRK3 | GRK3 | Homo sapiens | 30.0 |
| GRK4 | GRK4 | Homo sapiens | 50.0 |
| GRK7 | GRK7 | Homo sapiens | 0.0 |
| GSG2 | HASPIN | Homo sapiens | 3.0 |
| GSK3A | GSK3A | Homo sapiens | 37.0 |
| GSK3B | GSK3B | Homo sapiens | 4.0 |
| HCK | HCK | Homo sapiens | 0.0 |
| HIPK1 | HIPK1 | Homo sapiens | 39.0 |
| HIPK2 | HIPK2 | Homo sapiens | 3.0 |
| HIPK3 | HIPK3 | Homo sapiens | 0.0 |
| HIPK4 | HIPK4 | Homo sapiens | 18.0 |
| HUNK | HUNK | Homo sapiens | 10.0 |
| ICK | CILK1 | Homo sapiens | 0.0 |
| IGF1R | IGF1R | Homo sapiens | 5.0 |
| IKBKB | IKBKB | Homo sapiens | 5.0 |
| IKBKE | IKBKE | Homo sapiens | 3.0 |
| INSR | INSR | Homo sapiens | 0.0 |
| INSRR | INSRR | Homo sapiens | 0.0 |
| IRAK1 | IRAK1 | Homo sapiens | 0.0 |
| IRAK3 | IRAK3 | Homo sapiens | 0.0 |
| IRAK4 | IRAK4 | Homo sapiens | 0.0 |
| ITK | ITK | Homo sapiens | 0.0 |
| JAK1 | JAK1 | Homo sapiens | 0.0 |
| JAK1(Kin.Dom.1) | JAK1 | Homo sapiens | 9.0 |
| JAK2 | JAK2 | Homo sapiens | 0.0 |
| JAK3 | JAK3 | Homo sapiens | 0.0 |
| KIT | KIT | Homo sapiens | 0.0 |
| KIT(A829P) | KIT | Homo sapiens | 0.0 |
| KIT(D816H) | KIT | Homo sapiens | 0.0 |
| KIT(D816V) | KIT | Homo sapiens | 12.0 |
| KIT(L576P) | KIT | Homo sapiens | 0.0 |
| KIT(V559D) | KIT | Homo sapiens | 0.0 |
| KIT(V559D,T670I) | KIT | Homo sapiens | 0.0 |
| KIT(V559D,V654A) | KIT | Homo sapiens | 2.0 |
| KIT-autoinhibited | KIT | Homo sapiens | 4.0 |
| LATS1 | LATS1 | Homo sapiens | 0.0 |
| LATS2 | LATS2 | Homo sapiens | 0.0 |
| LCK | LCK | Homo sapiens | 9.0 |
| LIMK1 | LIMK1 | Homo sapiens | 6.0 |
| LIMK2 | LIMK2 | Homo sapiens | 1.0 |
| LRRK2 | LRRK2 | Homo sapiens | 8.0 |
| LRRK2(G2019S) | LRRK2 | Homo sapiens | 27.0 |
| LTK | LTK | Homo sapiens | 0.0 |
| LYN | LYN | Homo sapiens | 0.0 |
| MAK | MAK | Homo sapiens | 12.0 |
| MAP2K3 | MAP2K3 | Homo sapiens | 0.0 |
| MAP2K4 | MAP2K4 | Homo sapiens | 3.0 |
| MAP2K5 | MAP2K5 | Homo sapiens | 8.0 |
| MAP2K6 | MAP2K6 | Homo sapiens | 0.0 |
| MAP3K1 | MAP3K1 | Homo sapiens | 0.0 |
| MAP3K10 | MAP3K10 | Homo sapiens | 7.0 |
| MAP3K11 | MAP3K11 | Homo sapiens | 6.0 |
| MAP3K12 | MAP3K12 | Homo sapiens | 5.0 |
| MAP3K13 | MAP3K13 | Homo sapiens | 0.0 |
| MAP3K15 | MAP3K15 | Homo sapiens | 2.0 |
| MAP3K2 | MAP3K2 | Homo sapiens | 0.0 |
| MAP3K20 | MAP3K20 | Homo sapiens | 14.0 |
| MAP3K3 | MAP3K3 | Homo sapiens | 4.0 |
| MAP3K4 | MAP3K4 | Homo sapiens | 8.0 |
| MAP3K5 | MAP3K5 | Homo sapiens | 7.0 |
| MAP3K6 | MAP3K6 | Homo sapiens | 4.0 |
| MAP3K7 | MAP3K7 | Homo sapiens | 5.0 |
| MAP3K9 | MAP3K9 | Homo sapiens | 9.0 |
| MAP4K1 | MAP4K1 | Homo sapiens | 0.0 |
| MAP4K2 | MAP4K2 | Homo sapiens | 41.0 |
| MAP4K3 | MAP4K3 | Homo sapiens | 11.0 |
| MAP4K4 | MAP4K4 | Homo sapiens | 0.0 |
| MAP4K5 | MAP4K5 | Homo sapiens | 6.0 |
| MAPK1 | MAPK1 | Homo sapiens | 0.0 |
| MAPK10 | MAPK10 | Homo sapiens | 0.0 |
| MAPK11 | MAPK11 | Homo sapiens | 0.0 |
| MAPK12 | MAPK12 | Homo sapiens | 34.0 |
| MAPK14 | MAPK14 | Homo sapiens | 4.0 |
| MAPK15 | MAPK15 | Homo sapiens | 3.0 |
| MAPK3 | MAPK3 | Homo sapiens | 17.0 |
| MAPK4 | MAPK4 | Homo sapiens | 14.0 |
| MAPK6 | MAPK6 | Homo sapiens | 0.0 |
| MAPK7 | MAPK7 | Homo sapiens | 12.0 |
| MAPK8 | MAPK8 | Homo sapiens | 22.0 |
| MAPK9 | MAPK9 | Homo sapiens | 0.0 |
| MAPKAPK2 | MAPKAPK2 | Homo sapiens | 3.0 |
| MAPKAPK5 | MAPKAPK5 | Homo sapiens | 5.0 |
| MARK1 | MARK1 | Homo sapiens | 0.0 |
| MARK2 | MARK2 | Homo sapiens | 0.0 |
| MARK3 | MARK3 | Homo sapiens | 11.0 |
| MARK4 | MARK4 | Homo sapiens | 0.0 |
| MAST1 | MAST1 | Homo sapiens | 16.0 |
| MATK | MATK | Homo sapiens | 0.0 |
| MEK1 | MAP2K1 | Homo sapiens | 10.0 |
| MEK2 | MAP2K2 | Homo sapiens | 0.0 |
| MELK | MELK | Homo sapiens | 9.0 |
| MERTK | MERTK | Homo sapiens | 11.0 |
| MET | MET | Homo sapiens | 12.0 |
| MET(M1250T) | MET | Homo sapiens | 2.0 |
| MET(Y1235D) | MET | Homo sapiens | 4.0 |
| MINK1 | MINK1 | Homo sapiens | 6.0 |
| MKK7 | MAP2K7 | Homo sapiens | 0.0 |
| MKNK1 | MKNK1 | Homo sapiens | 3.0 |
| MKNK2 | MKNK2 | Homo sapiens | 0.0 |
| MST1R | MST1R | Homo sapiens | 0.0 |
| MST4 | STK26 | Homo sapiens | 6.0 |
| MTOR | MTOR | Homo sapiens | 40.0 |
| MUSK | MUSK | Homo sapiens | 0.0 |
| MYLK | MYLK | Homo sapiens | 27.0 |
| MYLK2 | MYLK2 | Homo sapiens | 0.0 |
| MYLK3 | MYLK3 | Homo sapiens | 2.0 |
| MYLK4 | MYLK4 | Homo sapiens | 4.0 |
| MYO3A | MYO3A | Homo sapiens | 13.0 |
| MYO3B | MYO3B | Homo sapiens | 0.0 |
| NDR1 | STK38 | Homo sapiens | 0.0 |
| NEK1 | NEK1 | Homo sapiens | 0.0 |
| NEK10 | NEK10 | Homo sapiens | 10.0 |
| NEK11 | NEK11 | Homo sapiens | 2.0 |
| NEK2 | NEK2 | Homo sapiens | 6.0 |
| NEK3 | NEK3 | Homo sapiens | 5.0 |
| NEK4 | NEK4 | Homo sapiens | 0.0 |
| NEK5 | NEK5 | Homo sapiens | 0.0 |
| NEK6 | NEK6 | Homo sapiens | 0.0 |
| NEK7 | NEK7 | Homo sapiens | 0.0 |
| NEK9 | NEK9 | Homo sapiens | 1.0 |
| NIK | MAP3K14 | Homo sapiens | 17.0 |
| NIM1 | NIM1K | Homo sapiens | 0.0 |
| NLK | NLK | Homo sapiens | 6.0 |
| NTRK1 | NTRK1 | Homo sapiens | 0.0 |
| NTRK2 | NTRK2 | Homo sapiens | 11.0 |
| NTRK3 | NTRK3 | Homo sapiens | 1.0 |
| NUAK1 | NUAK1 | Homo sapiens | 4.0 |
| OSR1 | OXSR1 | Homo sapiens | 0.0 |
| p38-delta | MAPK13 | Homo sapiens | 15.0 |
| PAK1 | PAK1 | Homo sapiens | 0.0 |
| PAK2 | PAK2 | Homo sapiens | 0.0 |
| PAK3 | PAK3 | Homo sapiens | 0.0 |
| PAK4 | PAK4 | Homo sapiens | 9.0 |
| PAK6 | PAK6 | Homo sapiens | 8.0 |
| PAK7 | PAK5 | Homo sapiens | 0.0 |
| PCTK1 | CDK16 | Homo sapiens | 0.0 |
| PCTK2 | CDK17 | Homo sapiens | 0.0 |
| PCTK3 | CDK18 | Homo sapiens | 0.0 |
| PDGFRA | PDGFRA | Homo sapiens | 25.0 |
| PDGFRB | PDGFRB | Homo sapiens | 0.0 |
| PDPK1 | PDPK1 | Homo sapiens | 22.0 |
| PFCDPK1(P.falciparum) | CDPK1 | Plasmodium falciparum | 15.0 |
| PFPK5(P.falciparum) | PK5 | Plasmodium falciparum | 0.0 |
| PFTAIRE2 | CDK15 | Homo sapiens | 0.0 |
| PFTK1 | CDK14 | Homo sapiens | 0.0 |
| PHKG1 | PHKG1 | Homo sapiens | 8.0 |
| PHKG2 | PHKG2 | Homo sapiens | 6.0 |
| PI4KB | PI4KB | Homo sapiens | 0.0 |
| PIK3C2B | PIK3C2B | Homo sapiens | 0.0 |
| PIK3C2G | PIK3C2G | Homo sapiens | 12.0 |
| PIK3C3 | PIK3C3 | Homo sapiens | 14.0 |
| PIK3CA | PIK3CA | Homo sapiens | 0.0 |
| PIK3CA(C420R) | PIK3CA | Homo sapiens | 0.0 |
| PIK3CA(E542K) | PIK3CA | Homo sapiens | 4.0 |
| PIK3CA(E545A) | PIK3CA | Homo sapiens | 5.0 |
| PIK3CA(E545K) | PIK3CA | Homo sapiens | 0.0 |
| PIK3CA(H1047L) | PIK3CA | Homo sapiens | 4.0 |
| PIK3CA(H1047Y) | PIK3CA | Homo sapiens | 27.0 |
| PIK3CA(I800L) | PIK3CA | Homo sapiens | 0.0 |
| PIK3CA(M1043I) | PIK3CA | Homo sapiens | 1.0 |
| PIK3CA(Q546K) | PIK3CA | Homo sapiens | 8.0 |
| PIK3CB | PIK3CB | Homo sapiens | 9.0 |
| PIK3CD | PIK3CD | Homo sapiens | 0.0 |
| PIK3CG | PIK3CG | Homo sapiens | 28.0 |
| PIKFYVE | PIKFYVE | Homo sapiens | 11.0 |
| PIM1 | PIM1 | Homo sapiens | 15.0 |
| PIM2 | PIM2 | Homo sapiens | 12.0 |
| PIM3 | PIM3 | Homo sapiens | 1.0 |
| PIP5K1A | PIP5K1A | Homo sapiens | 5.0 |
| PIP5K1C | PIP5K1C | Homo sapiens | 37.0 |
| PIP5K2B | PIP4K2B | Homo sapiens | 44.0 |
| PIP5K2C | PIP4K2C | Homo sapiens | 40.0 |
| PKAC-alpha | PRKACA | Homo sapiens | 16.0 |
| PKAC-beta | PRKACB | Homo sapiens | 5.0 |
| PKMYT1 | PKMYT1 | Homo sapiens | 0.0 |
| PKN1 | PKN1 | Homo sapiens | 37.0 |
| PKN2 | PKN2 | Homo sapiens | 14.0 |
| PKNB(M.tuberculosis) | PKNB | Mycobacterium tuberculosis | 0.0 |
| PLK1 | PLK1 | Homo sapiens | 5.0 |
| PLK2 | PLK2 | Homo sapiens | 35.0 |
| PLK3 | PLK3 | Homo sapiens | 0.0 |
| PLK4 | PLK4 | Homo sapiens | 0.0 |
| PNCK | PNCK | Homo sapiens | 0.0 |
| PRKAA1 | PRKAA1 | Homo sapiens | 0.0 |
| PRKAA2 | PRKAA2 | Homo sapiens | 12.0 |
| PRKCD | PRKCD | Homo sapiens | 0.0 |
| PRKCE | PRKCE | Homo sapiens | 45.0 |
| PRKCH | PRKCH | Homo sapiens | 44.0 |
| PRKCI | PRKCI | Homo sapiens | 18.0 |
| PRKCQ | PRKCQ | Homo sapiens | 3.0 |
| PRKD1 | PRKD1 | Homo sapiens | 6.0 |
| PRKD2 | PRKD2 | Homo sapiens | 4.0 |
| PRKD3 | PRKD3 | Homo sapiens | 6.0 |
| PRKG1 | PRKG1 | Homo sapiens | 7.0 |
| PRKG2 | PRKG2 | Homo sapiens | 6.0 |
| PRKR | EIF2AK2 | Homo sapiens | 16.0 |
| PRKX | PRKX | Homo sapiens | 0.0 |
| PRPF4B | PRPF4B | Homo sapiens | 0.0 |
| PTK2 | PTK2 | Homo sapiens | 5.0 |
| PTK2B | PTK2B | Homo sapiens | 0.0 |
| PTK6 | PTK6 | Homo sapiens | 0.0 |
| RAF1 | RAF1 | Homo sapiens | 6.0 |
| RET | RET | Homo sapiens | 2.0 |
| RET(M918T) | RET | Homo sapiens | 2.0 |
| RET(V804L) | RET | Homo sapiens | 3.0 |
| RET(V804M) | RET | Homo sapiens | 13.0 |
| RIOK1 | RIOK1 | Homo sapiens | 3.0 |
| RIOK2 | RIOK2 | Homo sapiens | 9.0 |
| RIOK3 | RIOK3 | Homo sapiens | 4.0 |
| RIPK1 | RIPK1 | Homo sapiens | 7.0 |
| RIPK2 | RIPK2 | Homo sapiens | 4.0 |
| RIPK4 | RIPK4 | Homo sapiens | 0.0 |
| RIPK5 | DSTYK | Homo sapiens | 0.0 |
| ROCK1 | ROCK1 | Homo sapiens | 0.0 |
| ROCK2 | ROCK2 | Homo sapiens | 0.0 |
| ROS1 | ROS1 | Homo sapiens | 18.0 |
| RPS6KA1(Kin.Dom.1) | RPS6KA1 | Homo sapiens | 0.0 |
| RPS6KA1(Kin.Dom.2) | RPS6KA1 | Homo sapiens | 5.0 |
| RPS6KA2(Kin.Dom.1) | RPS6KA2 | Homo sapiens | 3.0 |
| RPS6KA2(Kin.Dom.2) | RPS6KA2 | Homo sapiens | 9.0 |
| RPS6KA3(Kin.Dom.1) | RPS6KA3 | Homo sapiens | 0.0 |
| RPS6KA3(Kin.Dom.2) | RPS6KA3 | Homo sapiens | 0.0 |
| RPS6KA4(Kin.Dom.1) | RPS6KA4 | Homo sapiens | 7.0 |
| RPS6KA4(Kin.Dom.2) | RPS6KA4 | Homo sapiens | 12.0 |
| RPS6KA5(Kin.Dom.1) | RPS6KA5 | Homo sapiens | 42.0 |
| RPS6KA5(Kin.Dom.2) | RPS6KA5 | Homo sapiens | 17.0 |
| RPS6KA6(Kin.Dom.1) | RPS6KA6 | Homo sapiens | 0.0 |
| RPS6KA6(Kin.Dom.2) | RPS6KA6 | Homo sapiens | 23.0 |
| RPS6KB1 | RPS6KB1 | Homo sapiens | 0.0 |
| SBK1 | SBK1 | Homo sapiens | 0.0 |
| SGK1 | SGK1 | Homo sapiens | 2.0 |
| SgK110 | SBK3 | Homo sapiens | 0.0 |
| SGK2 | SGK2 | Homo sapiens | 18.0 |
| SGKL | SGK3 | Homo sapiens | 0.0 |
| SIK1 | SIK1 | Homo sapiens | 0.0 |
| SIK2 | SIK2 | Homo sapiens | 9.0 |
| SIK3 | SIK3 | Homo sapiens | 12.0 |
| SLK | SLK | Homo sapiens | 17.0 |
| SNARK | NUAK2 | Homo sapiens | 0.0 |
| SNRK | SNRK | Homo sapiens | 4.0 |
| SRC | SRC | Homo sapiens | 15.0 |
| SRMS | SRMS | Homo sapiens | 14.0 |
| SRPK1 | SRPK1 | Homo sapiens | 11.0 |
| SRPK2 | SRPK2 | Homo sapiens | 6.0 |
| SRPK3 | SRPK3 | Homo sapiens | 3.0 |
| STK10 | STK10 | Homo sapiens | 1.0 |
| STK11 | STK11 | Homo sapiens | 0.0 |
| STK16 | STK16 | Homo sapiens | 9.0 |
| STK17A | STK17A | Homo sapiens | 0.0 |
| STK17B | STK17B | Homo sapiens | 0.0 |
| STK24 | STK24 | Homo sapiens | 6.0 |
| STK25 | STK25 | Homo sapiens | 0.0 |
| STK3 | STK3 | Homo sapiens | 45.0 |
| STK32B | STK32B | Homo sapiens | 11.0 |
| STK32C | STK32C | Homo sapiens | 1.0 |
| STK33 | STK33 | Homo sapiens | 0.0 |
| STK35 | STK35 | Homo sapiens | 16.0 |
| STK36 | STK36 | Homo sapiens | 1.0 |
| STK38L | STK38L | Homo sapiens | 15.0 |
| STK39 | STK39 | Homo sapiens | 6.0 |
| STK4 | STK4 | Homo sapiens | 0.0 |
| SYK | SYK | Homo sapiens | 22.0 |
| TAOK1 | TAOK1 | Homo sapiens | 28.0 |
| TAOK2 | TAOK2 | Homo sapiens | 28.0 |
| TAOK3 | TAOK3 | Homo sapiens | 31.0 |
| TBK1 | TBK1 | Homo sapiens | 39.0 |
| TEC | TEC | Homo sapiens | 0.0 |
| TEK | TEK | Homo sapiens | 0.0 |
| TESK1 | TESK1 | Homo sapiens | 0.0 |
| TGFBR1 | TGFBR1 | Homo sapiens | 0.0 |
| TGFBR2 | TGFBR2 | Homo sapiens | 5.0 |
| TIE1 | TIE1 | Homo sapiens | 0.0 |
| TLK1 | TLK1 | Homo sapiens | 1.0 |
| TLK2 | TLK2 | Homo sapiens | 0.0 |
| TNIK | TNIK | Homo sapiens | 10.0 |
| TNK1 | TNK1 | Homo sapiens | 8.0 |
| TNK2 | TNK2 | Homo sapiens | 5.0 |
| TNNI3K | TNNI3K | Homo sapiens | 7.0 |
| TRPM6 | TRPM6 | Homo sapiens | 0.0 |
| TSSK1B | TSSK1B | Homo sapiens | 0.0 |
| TSSK3 | TSSK3 | Homo sapiens | 0.0 |
| TTK | TTK | Homo sapiens | 5.0 |
| TXK | TXK | Homo sapiens | 11.0 |
| TYK2(Kin.Dom.1) | TYK2 | Homo sapiens | 1.0 |
| TYK2(Kin.Dom.2) | TYK2 | Homo sapiens | 4.0 |
| TYRO3 | TYRO3 | Homo sapiens | 8.0 |
| ULK1 | ULK1 | Homo sapiens | 0.0 |
| ULK2 | ULK2 | Homo sapiens | 0.0 |
| ULK3 | ULK3 | Homo sapiens | 9.0 |
| VEGFR2 | KDR | Homo sapiens | 13.0 |
| VRK2 | VRK2 | Homo sapiens | 0.0 |
| WEE1 | WEE1 | Homo sapiens | 16.0 |
| WEE2 | WEE2 | Homo sapiens | 0.0 |
| WNK1 | WNK1 | Homo sapiens | 0.0 |
| WNK2 | WNK2 | Homo sapiens | 0.0 |
| WNK3 | WNK3 | Homo sapiens | 1.0 |
| WNK4 | WNK4 | Homo sapiens | 0.0 |
| YANK1 | STK32A | Homo sapiens | 0.0 |
| YES1 | YES1 | Homo sapiens | 1.0 |
| YSK4 | MAP3K19 | Homo sapiens | 12.0 |
| ZAP70 | ZAP70 | Homo sapiens | 1.0 |
RO4938581
The panel was screened with 10 µM compound.
Conclusion: Clean panel except for GABA-A (benzodiazapine binding site) with 97 % inhibition.
| Target protein | HGNC name | Species | % Inhibition at 10 µM | Mode of action |
|---|---|---|---|---|
| GABA-A (benzodiazapine binding site) | Rattus sp. | 97.0 | Binding | |
| histamine H1 receptor | HRH1 | Homo sapiens | 38.0 | Binding |
| adenosine A2A receptor | ADORA2A | Homo sapiens | 34.0 | Binding |
| choline transporter | SLC5A7 | Rattus norvegicus | 32.0 | Binding |
| nicotinic receptor, neuronal (alpha-Bungarotoxin insensitive) | Rattus sp. | 30.0 | Binding | |
| muscarinic receptor | Rattus sp. | 28.0 | Binding | |
| glutamate AMPA receptor | Rattus sp. | 27.0 | Binding | |
| neurokinin receptor 1 | TACR1 | Homo sapiens | 22.0 | Binding |
| imidazoline i1 receptor | NISCH | Bos taurus | 21.0 | Binding |
| V1a | AVPR1A | Homo sapiens | 20.0 | Binding |
| GABA transporter | Rattus sp. | 19.0 | Binding | |
| adenosine A1 receptor | ADORA1 | Homo sapiens | 18.0 | Binding |
| sodium channel (site 2) | SCN5A | Rattus norvegicus | 15.0 | Binding |
| GABA Cl- channel receptor | Rattus sp. | 11.0 | Binding | |
| histamine H3 receptor | HRH3 | Rattus sp. | 11.0 | Binding |
| PCP receptor | Rattus sp. | 11.0 | Binding | |
| adenosine A3 receptor | ADORA3 | Homo sapiens | 10.0 | Binding |
| Ca2+ channel (diltiazem site) | Rattus sp. | 10.0 | Binding | |
| glutamate NMDA receptor | Rattus sp. | 10.0 | Binding | |
| 5HT | Rattus sp. | 8.0 | Binding | |
| dopamine D1 receptor | DRD1 | Homo sapiens | 8.0 | Binding |
| dopamine D2 receptor (short) | DRD2 | Homo sapiens | 8.0 | Binding |
| peripheral-type benzodiazepine receptor | Rattus sp. | 8.0 | Binding | |
| dopamine D3 receptor | DRD3 | Homo sapiens | 7.0 | Binding |
| neurokinin receptor 3 | TACR3 | Homo sapiens | 7.0 | Binding |
| neuropeptide y receptor | Rattus sp. | 7.0 | Binding | |
| v2 | AVPR2 | Homo sapiens | 6.0 | Binding |
| angiotensin ii receptor 2 | AGTR2 | Homo sapiens | 5.0 | Binding |
| ca2+ channel (l-type) | Rattus sp. | 5.0 | Binding | |
| alpha1-adrenoceptor | Rattus sp. | 4.0 | Binding | |
| cholecystokinin 1 receptor | CCKAR | Homo sapiens | 4.0 | Binding |
| k+ channels kATP | Rattus sp. | 4.0 | Binding | |
| P2Y purinoceptors | Rattus sp. | 4.0 | Binding | |
| small conductance Ca2+ activated K+ channel | Rattus sp. | 4.0 | Binding | |
| thyrotropin-releasing hormone receptor | TRHR | Rattus sp. | 4.0 | Binding |
| cannabinoid receptor cb1 | CNR1 | Homo sapiens | 3.0 | Binding |
| estrogen receptor | ESR1 | Homo sapiens | 3.0 | Binding |
| glucocorticoid receptor | NR3C1 | Homo sapiens | 3.0 | Binding |
| norepinephrine transporter | SLC6A2 | Homo sapiens | 3.0 | Binding |
| alpha2-adrenoceptor | Rattus sp. | 2.0 | Binding | |
| glutamate kainate receptor | Rattus sp. | 2.0 | Binding | |
| histamine h2 receptor | HRH2 | Homo sapiens | 2.0 | Binding |
| beta2-adrenoceptor | ADRB2 | Homo sapiens | 1.0 | Binding |
| endothelin b receptor | EDNRB | Homo sapiens | 1.0 | Binding |
| MC4R | MC4R | Homo sapiens | 1.0 | Binding |
| neurokinin receptor 2 | TACR2 | Homo sapiens | 1.0 | Binding |
| cannabinoid receptor cb2 | CNR2 | Homo sapiens | 0.0 | Binding |
| leukotriene ltd4 receptor | CYSLTR1 | Homo sapiens | 0.0 | Binding |
| GABA | Rattus sp. | -1.0 | Binding | |
| progesterone receptor | PGR | Homo sapiens | -1.0 | Binding |
| bradykinin 2 receptor | BDKRB2 | Homo sapiens | -2.0 | Binding |
| corticotropin releasing factor 1 receptor | CRHR1 | Rattus sp. | -2.0 | Binding |
| serotonin transporter | SLC6A4 | Homo sapiens | -2.0 | Binding |
| androgen receptor | AR | Homo sapiens | -3.0 | Binding |
| angiotensin ii receptor 1 | AGTR1 | Homo sapiens | -3.0 | Binding |
| bradykinin 1 receptor | BDKRB1 | Homo sapiens | -3.0 | Binding |
| P2X purinoceptors | Rattus sp. | -4.0 | Binding | |
| k+ channels KV | Rattus sp. | -5.0 | Binding | |
| beta1-adrenoceptor | ADRB1 | Homo sapiens | -7.0 | Binding |
| sigma | Rattus sp. | -9.0 | Binding | |
| orphanin orl1 receptor | OPRL1 | Homo sapiens | -10.0 | Binding |
| endothelin a receptor | EDNRA | Homo sapiens | -13.0 | Binding |
| cholecystokinin 2 receptor | CCKBR | Homo sapiens | -16.0 | Binding |
| opioid receptor | Rattus sp. | -16.0 | Binding | |
| imidazoline i2 receptor | Rattus sp. | -17.0 | Binding | |
| dopamine d4 receptor | DRD4 | Homo sapiens | -18.0 | Binding |
| ca2+ channel (verapamil site) | Rattus sp. | -20.0 | Binding | |
| dopamine transporter | SLC6A3 | Homo sapiens | -29.0 | Binding |
| PPARalpha | PPARA | Homo sapiens | -19.0 | Cellular |
| monoamine oxidase-b | MAOB | Homo sapiens | 28.0 | Enzymatic |
| phosphodiesterase 4 | Homo sapiens | 22.0 | Enzymatic | |
| GABA transaminase | Rattus sp. | 15.0 | Enzymatic | |
| phosphodiesterase 2 | PDE2A | Homo sapiens | 11.0 | Enzymatic |
| phosphodiesterase 5 | PDE5A | Homo sapiens | 11.0 | Enzymatic |
| phosphodiesterase 1 | Bos taurus | 10.0 | Enzymatic | |
| protein kinase c | Rattus sp. | 9.0 | Enzymatic | |
| phosphodiesterase 3 | Homo sapiens | 7.0 | Enzymatic | |
| monoamine oxidase-a | MAOA | Homo sapiens | 5.0 | Enzymatic |
| ATPase | Canis lupus familiaris | 4.0 | Enzymatic | |
| acetylcholinesterase | ACHE | Homo sapiens | 1.0 | Enzymatic |
| tyrosine hydroxylase | TH | Rattus sp. | -1.0 | Enzymatic |
| COMT | COMT | Sus scrofa | -4.0 | Enzymatic |
| PNMT | PMNT | Bos taurus | -19.0 | Enzymatic |