Physicochemical properties of probe RO4938581 and control RO4991571
| RO4938581 | |
|---|---|
| log D (pH 7.4) | 1.6 |
| RO4991571 | |
|---|---|
| log D (pH 7.4) | 2.0 |
Solubility
| RO4938581: |
0.05M H2PO4 pH 6.5: 16.7 µg/mL,
0.2M H2PO4 pH 7.4: 12.9 µg/mL,
FaSSIF pH 6.5: 28.6 µg/mL,
FeSSIF pH 5.0: 48.6 µg/mL,
FaSSGF pH 1.6: 29.9 µM/mL,
Lyophilisation solubility assay (LYSA): 19 mg/L
|
| RO4991571: |
Lyophilisation solubility assay (LYSA): 21.5 µg/mL
|