KISS1-305
| Target | KISS1R |
| Targeted domain | Kisspeptin binding site |
| Mode of action | Agonist |
| Control | KISS1-543 |
| Recommended cellular usage concentration | 1 - 1000 nM |
| In vivo use | yes |
| Synonyms | TP-005 |
| Donated by | Takeda |
Probe criteria
| Selectivity within target family: > 30 fold | Binding against NPFFR2 (GPR74) and NPFFR1 (GPR147) >30 foldClean PDSP scan with the exception for OPRD1 (Ki = 47.5 nM, n= 2) |
| Selectivity outside target family | Coming soon. |
| On target cell activity for cell-based targets: goal is < 1 µM IC50/EC50 | KISS1R expressing cell growth IC50 = 8.94 nM |
| Control peptide (100 times less potent than the probe) | Agonist activity for hKISS1R(C-terminal ethyl amide) EC50 > 10 µM Clean PDSP scan |
| In vitro potency < 100 nM | Ki = 0.089 nM |