Physicochemical properties of probe BAY-6096 and control BAY-726
| BAY-6096 | |
|---|---|
| TPSA | 88 Å2 |
| Stability pH 7.4 | 13 h at RT |
| log D (pH 7.5) | 1.2 |
| Ligand-lipophilicity efficiency (LLE, based on hIC50) | 6.7 |
| Binding efficiency index (BEI) | 20.0 |
| BAY-726 | |
|---|---|
| TPSA | 80 Å2 |
| Stability pH 1/7/10 | 24 h at 37°C |
| log D (pH 7.5) | 1.3 |
| Ligand-lipophilicity efficiency (LLE, based on hIC50) | 4.0 |
| Binding efficiency index (BEI) | 12.0 |
Solubility
| BAY-6096: |
aqueous solution pH 6.5 (crystalline material): > 90 g/L
|
| BAY-726: |
aqueous solution pH 7.4 (crystalline material): > 500 mg/L
|