In cells

Use at a concentration of 100 nM.

Use the recommended concentration to avoid off-target toxicity and/or off-target activity. Using concentrations that are higher than recommended could lead to false positive or confounding results.

In vivo

Tested in rat with up to 0.3 mg/kg iV. The formate of BAY-6096 (compound 45 in PMID 36932954) dose dependently decreases the blood pressure increase induced by ADRA2B agonist compound 44 in PMID: 36932954 thereby suggesting a role for ADRA2B in vascular constriction in rats.