Physicochemical properties of probe CCT369260 and control CCT393732
| CCT369260 | |
|---|---|
| TPSA | 84.83 Å2 |
| log D (pH 7.4), experimental | 4.3 |
| Ligand efficiency (LE) | 0.3 |
| Ligand-lipophilicity efficiency (LLE) | 1.9 |
| CCT393732 | |
|---|---|
| log D (pH 7.4), calculated | 4.5 |
Solubility
| CCT369260: |
Kinetic solubility measured by NMR (HEPES buffer, 5% DMSO), pH 8: 11 µM,
Kinetic solubility measured by measured by HPLC (PBS buffer, 1% DMSO), pH 7.4: 8 µM
|
| CCT393732: |
Aqueous solubility: 53 µM
|