Physicochemical properties of GSK620
| GSK620 | |
|---|---|
| Artificial Membrane Permeability (AMP) | 200 nm/s |
| Appearance | colorless solid |
| Chrom log D pH 7.4 | 3.1 |
| C log P | 0.1 |
| BRD4 DB2 ligand efficiency (LE) | 0.4 |
| Ligand-lipophilicity efficiency (LLE) AT | 0.5 |
Solubility
| GSK620: |
FaSSIF (fasted state simulated intestinal fluid): 13 - 35 µg/mL,
Kinetic aqueous solubility measured with Chemiluminescent Nitrogen Detection (CLND): > 154 µg/mL
|