Physicochemical properties of JNJ-4355
| JNJ-4355 | |
|---|---|
| EPSA | 151 Å2 |
| CHI log D (pH 7.4) | 2.4 |
| pKa (1) | 4.2 |
| pKa (2) | 1.9 |
Solubility
| JNJ-4355: |
30% HP-b-CD, pH 8.1 : 12.9 mg/mL,
Equilibrium solubility, pH = 7: 2.4 mg/mL,
Saline solubility, pH 8.6 : 12 mg/mL
|