In cells

Use at a concentration up to 10 µM.

Use the recommended concentration to avoid off-target toxicity and/or off-target activity. Using concentrations that are higher than recommended could lead to false positive or confounding results.

In vivo

Tested in vivo: Tested in mouse and rat (dose IV bolus 1 mg/kg); JNJ-4355 disrupts MCL1 complexes in MOLM-13 (AML) human xenograft. A single 10 mg/kg IV bolus dose in mouse eradicates tumors for over 25 days.