In cells

Use at a concentration of 100 nM.

Due to the high potency for oxytocin, we recommend to use BAY 1753011 together with the oxytocin antagonist (Ki 4.6 nM, selectivity vs AVPR1A and AVPR2 > 695) L-371,257.

Use the recommended concentration to avoid off-target toxicity and/or off-target activity. Using concentrations that are higher than recommended could lead to false positive or confounding results.

In vivo

Good for in vivo use: Pecavaptan (0.01 to 0.3 mg/kg; IV; single dose) protects from arginine vasopressin-mediated cardiac output in canine tachypacing-induced model of heart failure; shows pronounced effects on human platelet aggregation and on vasopressin-induced vasoconstriction; Dose-dependent reduction of vasopressin-induced blood pressure increase in rats.