In cells

Use at concentration up to 1 µM.

We recommend to use the AKT1/2 inhibitor Borussertib also available from SGC for control experiments.

Use the recommended concentration to avoid off-target toxicity and/or off-target activity. Using concentrations that are higher than recommended could lead to false positive or confounding results.

In vivo

BAY1125976 demonstrates potent anti-tumor efficacy in KPL-4 breast cancer (PIK3CA (H1047R), HER2 (O/E)) nude mice model (Dose: 25 -50 mg/kg po QD)