In cells

Use at concentration of about 200 nM.

We recommend to use the FFAR1 inhibitor TP-051 also available from SGC for control experiments.

Use the recommended concentration to avoid off-target toxicity and/or off-target activity. Using concentrations that are higher than recommended could lead to false positive or confounding results.

In vivo

Tested in rats with oral (10 mg/kg) and intravenous (1 mg/kg) administration. Shows high bioavailability and strong glucose lowering effect and increase of the plasma insulin level in male Zucker diabetic fatty (ZDF) rats compared to untreated ZDF rats.