In cells

Use at concentration up to 1 µM.

We recommend to use the FFAR1 inhibitor BI-2081 also available from SGC for control experiments.

Use the recommended concentration to avoid off-target toxicity and/or off-target activity. Using concentrations that are higher than recommended could lead to false positive or confounding results.

In vivo

TP-051 shows a significant plasma glucose-lowering effect and insulinotropic action during an oral glucose tolerance test in rats with impaired glucose tolerance at 0.3 mg/kg . Recommended in vivo dose is 30 mg/kg or less.