Physicochemical properties of probe RO-275 and control RO7239047
| RO-275 | |
|---|---|
| log D (pH 7.4) | 2.7 |
| pKa (basic) | 2.4 |
| RO7239047 | |
|---|---|
| log D (pH 7.4) | 2.4 |
| pKa (basic) | 2.8 |
Solubility
| RO-275: |
Kinetic solubility (HT): 0.05M Phosphate pH 6.5: 57 µM,
Kinetic solubility (HT): FESSIF pH 5.0: 28 µM,
Thermodynamic solubility: FaSSGF pH 1.61: 6 µM,
Thermodynamic solubility: FeSSIF pH 5.0: 11 µM,
Thermodynamic solubility: 0.05M Phosphate pH 6.5: < 0.3 µM,
Thermodynamic solubility: FaSSIF pH 6.5: 2 µM,
Thermodynamic solubility: 0.02M Phosphate + NaCl pH 7.4: < 0.3 µM
|
| RO7239047: |
Kinetic solubility (HT): 0.05M Phosphate pH 6.5: 380 µg/mL
|