Physicochemical properties of JNJ-6204
| JNJ-6204 | |
|---|---|
| Measured log D (pH 2.6) | 1.4 |
| Measured log D (pH 7.4) | 1.4 |
| Measured log D (pH 10.5) | 1.5 |
| Calculated P log D | 1.8 |
| Ligand efficiency (LE) (BRET) | 0.4 |
| Ligand efficiency (LE) (ADP) | 0.4 |
| Ligand-lipophilicity efficiency (LLE) (BRET) | 5.4 |
| Ligand-lipophilicity efficiency (LLE) (ADP) | 6.6 |
| cLog P | 1.8 |
| MPO | 5.8 |
| TPSA | 81.5 Å2 |
Solubility
| JNJ-6204: |
aqueous, pH 7: 22 µM,
aqueous, pH 2: 84 µM,
SGF: > 400 µM,
FaSIF: 64 µM
|